[Science Magazine] Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in

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[Science Magazine] Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in

Post by RSS Fetch » Thu Jan 10, 2019 6:37 pm

Phase variation, the reversible alternation between genetic states, enables infection by pathogens and colonization by commensals. However, the diversity of phase variation remains underexplored. We developed the PhaseFinder algorithm to quantify DNA inversion–mediated phase variation. A systematic search of 54,875 bacterial genomes identified 4686 intergenic invertible DNA regions (invertons), revealing an enrichment in host-associated bacteria. Invertons containing promoters often regulate extracellular products, underscoring the importance of surface diversity for gut colonization. We found invertons containing promoters regulating antibiotic resistance genes that shift to the ON orientation after antibiotic treatment in human metagenomic data and in vitro, thereby mitigating the cost of antibiotic resistance. We observed that the orientations of some invertons diverge after fecal microbiota transplant, potentially as a result of individual-specific selective forces.

Source: http://science.sciencemag.org/cgi/conte ... /181?rss=1

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Gord
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Re: [Science Magazine] Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptatio

Post by Gord » Fri Jan 11, 2019 12:51 am

Okay, now THIS title sounds like a randomly generated string of words! :mrgreen:

https://scratch.mit.edu/projects/14635604/

Simulating Neural Networks Using Game-Theoretic Models
Pervasive Modalities
Decoupling Information Retrieval Systems from XML in Interrupts

Daaaamn, theirs is better than the ones I came up with....
"Knowledge grows through infinite timelessness" -- the random fictional Deepak Chopra quote site
"Imagine an ennobling of what could be" -- the New Age BS Generator site
"You are also taking my words out of context." -- Justin
"Nullius in verba" -- The Royal Society ["take nobody's word for it"]
#ANDAMOVIE
Is Trump in jail yet?