New info on the genetics of ADHD

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Nikki Nyx
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New info on the genetics of ADHD

Post by Nikki Nyx » Tue Aug 08, 2017 6:58 pm

A new study in Biological Psychiatry suggests how the risk gene ADGRL3 (LPHN3) might work. ADGRL3 encodes the protein latrophilin 3, which regulates communication between brain cells. According to the study, a common variation of the gene associated with ADHD disrupts its ability to regulate gene transcription -- the formation of mRNA from DNA that leads to expression of the gene.
The researchers analyzed the ADGRL3 genomic region in 838 people, 372 of whom were diagnosed with ADHD. Variants in one particular segment within the gene, the transcriptional enhancer ECR47, showed the highest association with ADHD and with other disorders that commonly occur alongside ADHD, such as disruptive behaviors and substance use disorder.

ECR47 functions as a transcriptional enhancer to boost gene expression in the brain. However, the researchers found that a variation of ECR47 associated with ADHD disrupted ECR47's ability to bind an important neurodevelopmental transcription factor, YY1 -- an indication that the risk variant interferes with gene transcription.

In an analysis of postmortem human brain tissue from 137 control subjects, they also found an association between the ECR47 risk variant and reduced ADGRL3 expression in the thalamus, a key brain region for coordinating sensory processing in the brain. The findings link the gene to a potential mechanism for ADHD pathophysiology.
Read the entire study here.
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Re: New info on the genetics of ADHD

Post by Gord » Wed Aug 09, 2017 12:36 pm

tl;dr
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Re: New info on the genetics of ADHD

Post by bobbo_the_Pragmatist » Wed Aug 09, 2017 3:22 pm

Too long? Nay. Its something else. What I see is numbers and letters mixed up.

................ I know.
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Nikki Nyx
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Re: New info on the genetics of ADHD

Post by Nikki Nyx » Wed Aug 09, 2017 10:32 pm

Gord wrote:tl;dr
:laff:
"An extraordinary claim requires extraordinary proof."—Marcello Truzzi

"What can be asserted without evidence can also be dismissed without evidence."—Christopher Hitchens