New info on the genetics of ADHD

What you think about how you think.
User avatar
Nikki Nyx
Veteran Poster
Posts: 2042
Joined: Wed Jun 07, 2017 12:40 am
Custom Title: cognitively consonant
Location: playing croquet in Wonderland

New info on the genetics of ADHD

Postby Nikki Nyx » Tue Aug 08, 2017 6:58 pm

A new study in Biological Psychiatry suggests how the risk gene ADGRL3 (LPHN3) might work. ADGRL3 encodes the protein latrophilin 3, which regulates communication between brain cells. According to the study, a common variation of the gene associated with ADHD disrupts its ability to regulate gene transcription -- the formation of mRNA from DNA that leads to expression of the gene.
The researchers analyzed the ADGRL3 genomic region in 838 people, 372 of whom were diagnosed with ADHD. Variants in one particular segment within the gene, the transcriptional enhancer ECR47, showed the highest association with ADHD and with other disorders that commonly occur alongside ADHD, such as disruptive behaviors and substance use disorder.

ECR47 functions as a transcriptional enhancer to boost gene expression in the brain. However, the researchers found that a variation of ECR47 associated with ADHD disrupted ECR47's ability to bind an important neurodevelopmental transcription factor, YY1 -- an indication that the risk variant interferes with gene transcription.

In an analysis of postmortem human brain tissue from 137 control subjects, they also found an association between the ECR47 risk variant and reduced ADGRL3 expression in the thalamus, a key brain region for coordinating sensory processing in the brain. The findings link the gene to a potential mechanism for ADHD pathophysiology.
Read the entire study here.
What are the facts? Again and again and again-what are the facts? Shun wishful thinking, ignore divine revelation, forget what “the stars foretell,” avoid opinion, care not what the neighbors think, never mind the unguessable “verdict of history”--what are the facts, and to how many decimal places? You pilot always into an unknown future; facts are your single clue. Get the facts!
—Lazarus Long, from Time Enough for Love, by Robert A. Heinlein

User avatar
Gord
Real Skeptic
Posts: 29108
Joined: Wed Apr 29, 2009 2:44 am
Custom Title: Silent Ork
Location: Transcona

Re: New info on the genetics of ADHD

Postby Gord » Wed Aug 09, 2017 12:36 pm

tl;dr
"Knowledge grows through infinite timelessness" -- the random fictional Deepak Chopra quote site
"You are also taking my words out of context." -- Justin
"Nullius in verba" -- The Royal Society ["take nobody's word for it"]
#ANDAMOVIE

bobbo_the_Pragmatist
True Skeptic
Posts: 10235
Joined: Wed Sep 09, 2015 9:39 am

Re: New info on the genetics of ADHD

Postby bobbo_the_Pragmatist » Wed Aug 09, 2017 3:22 pm

Too long? Nay. Its something else. What I see is numbers and letters mixed up.

................ I know.
Real Name: bobbo the existential pragmatic evangelical anti-theist and Class Warrior.
Asking: What is the most good for the most people?
Sample Issue: Should the Feds provide all babies with free diapers?

User avatar
Nikki Nyx
Veteran Poster
Posts: 2042
Joined: Wed Jun 07, 2017 12:40 am
Custom Title: cognitively consonant
Location: playing croquet in Wonderland

Re: New info on the genetics of ADHD

Postby Nikki Nyx » Wed Aug 09, 2017 10:32 pm

Gord wrote:tl;dr
:laff:
What are the facts? Again and again and again-what are the facts? Shun wishful thinking, ignore divine revelation, forget what “the stars foretell,” avoid opinion, care not what the neighbors think, never mind the unguessable “verdict of history”--what are the facts, and to how many decimal places? You pilot always into an unknown future; facts are your single clue. Get the facts!
—Lazarus Long, from Time Enough for Love, by Robert A. Heinlein


Return to “Brain, Mind, & Consciousness”

Who is online

Users browsing this forum: No registered users and 1 guest